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OBJECTIVE:To provide reference for standardizing the names and definitions for the processing methods of"gener-al principles for processing"in reprinted Chinese Pharmacopoeia. METHODS:Comparing with the Processing of Chinese Mate-ria,Beijing Processing Specification for TCM Decoction Pieces,Shennong Bencaojing and National Processing Specification for Chinese Herbal Medicine,parts of the name and definition problems for processing methods of"general principles for processing"in Chinese Pharmacopoeia (2015 edition,Vol Ⅳ) were analyzed,and suggestions were put forward. RESULTS:The definitions of partial items in the"general principles for processing"in Chinese Pharmacopoeia remained to be normalized and operability re-mained to be improved. For example,the definitions of stir-frying,stir-frying with wine,stir-frying with vinegar,stir-frying with salt and stir-frying with honey were not accurate,so as the steaming. The name of the processing method under the term of decoc-tion pieces was not identified,there was deviation in the scope of crystallizing definition,and amount of pharmaceutic adjuvant was not worthy to be generalized. CONCLUSIONS:When generalizing and defining the processing methods for all TCM decoction pieces,Chinese Pharmacopoeia should give consideration to the popularity,accuracy and universality.
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OBJECTIVE:To systematically review the efficacy and safety of insulin glargine versus insulin detemir in the treat-ment of type 2 diabetes,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,EM-Base,Cochrane Library,CBM,CJFD,VIP and Wanfang database,randomized controlled trials (RCT) about the clinical efficacy and safety of insulin glargine versus insulin detemir in the treatment of type 2 diabetes were collected. Meta-analysis was performed by using Rev Man 5.2 software after data extraction and quality evaluation by Cochrane 5.1.0. RESULTS:A total of 18 RCTs,in-volving 3 638 patients were included. Results of Meta-analysis showed there was no significant difference in reducing glycosylated hemoglobin[MD=0.08,95%CI (-0.01,0.17),P=0.09];fasting blood glucose level in insulin glargine group was significantly lower thaninsulin detemir,the difference was statistically significant [MD=0.15,95%CI(0.03,0.27),P=0.02]. And there was no significant difference in the incidence of hypoglycemia [OR=0.97,95%CI(0.91,1.03),P=0.25];the degree of body mass gain ininsulin detemir was significantly lower than insulin glargine group [MD=-0.95,95%CI(-1.06,-0.85),P=0.003],but the in-cidence of injection site reactions was significantly higher than insulin glargine group [OR=2.28,95%CI(1.16,4.50),P=0.02],the differences were statistically significant. CONCLUSIONS:The insulin glargine has better efficacy,than insulin detemir with lower incidence of injection site reactions but higher degree of body mass gain than insulin detemir in the treatment of type 2 diabetes.
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Objective To investigate the effects of different processing methods on contents of main chemical components isoferulic acid in Cimicifuga heracleifolia. Methods Cimicifuga heracleifolia from the same batch were prepared by processing method. HPLC were used to determine the contents of isoferulic acid in crudes samples, wine-prepared samples, vinegar-prepared samples, and carbonized samples. Results The contents of isoferulic acid of crudes samples and the three different processed products were in the order as follows:carbonized samples (0.404 7%)>vinegar-prepared samples (0.302 3%)>wine-prepared samples (0.262 4%)>crudes samples (0.231 3%). Conclusion Different processing methods had certain effects on the content of isoferulic acid in Cimicifuga heracleifolia.
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Objective To explore the relationship between Qi_stagnation with blood stasi s, Qi_deficiency with blood stasis and platelet activation. Methods Expressi on levels of lysosomal integral membrane protein (CD?63), alpha_granu le membrane protein (CD?62?p) and thrombospondin (TSP)were the specific index es of platelet activation. Te chnique of monoclonal antibody analysis and flow cytometry were used to detect the expression levels of CD?63, CD?62?p and TSP. Fifty_eight cases of Qi_st agnation with blood stasis syndrome were allocated to Group A and 60 cases of Qi _deficiency with blood stasis syndrome to Group B, and 30 healthy volunteers ser ved as the control (Group C). Results Expression levels of CD63, CD62p an d TSP were higher in Group A than in Group B and Group C (P